الفرق بين المراجعتين لصفحة: «كيتوكونازول»

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==المرة الدوائية==
{{Drugbox
| English = Ketoconazole
| verifiedrevid = 457114462
| IUPAC_name = 1-[4-(4-{[(2''R'',4''S'')-2-(2,4-Dichlorophenyl)-2-(1''H''-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one
| image = Ketoconazole2.png
| width = 300
| image2 = Ketoconazole 3D balls 1jin.png
| width2 = 200


<!-- Clinical data -->
| tradename = Nizoral
| Drugs.com = {{drugs.com|monograph|ketoconazole}}
| MedlinePlus = a682816
| pregnancy_AU      = B3
| pregnancy_US      = C
| legal_UK = POM
| legal_US = OTC
| routes_of_administration = [[Oral administration|Oral]], [[topical]]
| licence_US        = Ketoconazole
<!-- Pharmacokinetic data -->
| bioavailability = Variable
| protein_bound = 84 to 99%
| metabolism = [[Liver|Hepatic]]
| elimination_half-life = Biphasic:
| excretion = Biliary and [[Kidney|renal]]
<!-- Identifiers -->
| CASNo_Ref = {{cascite|correct|CAS}}
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 65277-42-1
| ATC_prefix = J02
| ATC_suffix = AB02
| ATC_supplemental = {{ATC|D01|AC08}} {{ATC|G01|AF11}}
| PubChem = 456201
| IUPHAR_ligand = 2568
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB01026
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 401695
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = R9400W927I
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00351
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 48336
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 75
<!-- Chemical data -->
| C=26 | H=28 | Cl=2 | N=4 | O=4
| molecular_weight = 531.431 [[Gram|g]]/[[Mole (unit)|mol]]
| smiles = O=C(N5CCN(c4ccc(OC[C@@H]1O[C@](OC1)(c2ccc(Cl)cc2Cl)Cn3ccnc3)cc4)CC5)C
| InChI = 1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
| InChIKey = XMAYWYJOQHXEEK-OZXSUGGEBE
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = XMAYWYJOQHXEEK-OZXSUGGESA-N
}}
{{Drugbox
| English = Ketoconazole
| verifiedrevid = 457114462
| IUPAC_name = 1-[4-(4-{[(2''R'',4''S'')-2-(2,4-Dichlorophenyl)-2-(1''H''-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one
| image = Ketoconazole2.png
| width = 300
| image2 = Ketoconazole 3D balls 1jin.png
| width2 = 200
<!-- Clinical data -->
| tradename = Nizoral
| Drugs.com = {{drugs.com|monograph|ketoconazole}}
| MedlinePlus = a682816
| pregnancy_AU      = B3
| pregnancy_US      = C
| legal_UK = POM
| legal_US = OTC
| routes_of_administration = [[Oral administration|Oral]], [[topical]]
| licence_US        = Ketoconazole
<!-- Pharmacokinetic data -->
| bioavailability = Variable
| protein_bound = 84 to 99%
| metabolism = [[Liver|Hepatic]]
| elimination_half-life = Biphasic:
| excretion = Biliary and [[Kidney|renal]]
<!-- Identifiers -->
| CASNo_Ref = {{cascite|correct|CAS}}
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 65277-42-1
| ATC_prefix = J02
| ATC_suffix = AB02
| ATC_supplemental = {{ATC|D01|AC08}} {{ATC|G01|AF11}}
| PubChem = 456201
| IUPHAR_ligand = 2568
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB01026
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 401695
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = R9400W927I
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00351
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 48336
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 75
<!-- Chemical data -->
| C=26 | H=28 | Cl=2 | N=4 | O=4
| molecular_weight = 531.431 [[Gram|g]]/[[Mole (unit)|mol]]
| smiles = O=C(N5CCN(c4ccc(OC[C@@H]1O[C@](OC1)(c2ccc(Cl)cc2Cl)Cn3ccnc3)cc4)CC5)C
| InChI = 1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
| InChIKey = XMAYWYJOQHXEEK-OZXSUGGEBE
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = XMAYWYJOQHXEEK-OZXSUGGESA-N
}}
'''كيتوكونازول (Ketoconazole)'''
==الزمرة الدوائية==
مضاد فطري يستخدم جهازياً وموضعياً
مضاد فطري يستخدم جهازياً وموضعياً



مراجعة 14:13، 14 أغسطس 2013

{{Drugbox | English = Ketoconazole | verifiedrevid = 457114462 | IUPAC_name = 1-[4-(4-{[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one | image = Ketoconazole2.png | width = 300 | image2 = Ketoconazole 3D balls 1jin.png | width2 = 200

| tradename = Nizoral | Drugs.com = monograph | MedlinePlus = a682816 | pregnancy_AU = B3 | pregnancy_US = C | legal_UK = POM | legal_US = OTC | routes_of_administration = Oral, topical | licence_US = Ketoconazole

| bioavailability = Variable | protein_bound = 84 to 99% | metabolism = Hepatic | elimination_half-life = Biphasic: | excretion = Biliary and renal

| CASNo_Ref =  YesY | CAS_number_Ref =  YesY | CAS_number = 65277-42-1 | ATC_prefix = J02 | ATC_suffix = AB02 | ATC_supplemental = D01AC08 G01AF11 | PubChem = 456201 | IUPHAR_ligand = 2568 | DrugBank_Ref =  قالب:علامة اختيار

| DrugBank = DB01026

| ChemSpiderID_Ref =  YesY | ChemSpiderID = 401695 | UNII_Ref =  YesY | UNII = R9400W927I | KEGG_Ref =  YesY | KEGG = D00351 | ChEBI_Ref =  YesY | ChEBI = 48336 | ChEMBL_Ref =  YesY | ChEMBL = 75

| C=26 | H=28 | Cl=2 | N=4 | O=4 | molecular_weight = 531.431 g/mol | smiles = O=C(N5CCN(c4ccc(OC[C@@H]1O[C@](OC1)(c2ccc(Cl)cc2Cl)Cn3ccnc3)cc4)CC5)C | InChI = 1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1 | InChIKey = XMAYWYJOQHXEEK-OZXSUGGEBE | StdInChI_Ref =  YesY | StdInChI = 1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1 | StdInChIKey_Ref =  YesY | StdInChIKey = XMAYWYJOQHXEEK-OZXSUGGESA-N }} {{Drugbox | English = Ketoconazole | verifiedrevid = 457114462 | IUPAC_name = 1-[4-(4-{[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one | image = Ketoconazole2.png | width = 300 | image2 = Ketoconazole 3D balls 1jin.png | width2 = 200

| tradename = Nizoral | Drugs.com = monograph | MedlinePlus = a682816 | pregnancy_AU = B3 | pregnancy_US = C | legal_UK = POM | legal_US = OTC | routes_of_administration = Oral, topical | licence_US = Ketoconazole

| bioavailability = Variable | protein_bound = 84 to 99% | metabolism = Hepatic | elimination_half-life = Biphasic: | excretion = Biliary and renal

| CASNo_Ref =  YesY | CAS_number_Ref =  YesY | CAS_number = 65277-42-1 | ATC_prefix = J02 | ATC_suffix = AB02 | ATC_supplemental = D01AC08 G01AF11 | PubChem = 456201 | IUPHAR_ligand = 2568 | DrugBank_Ref =  قالب:علامة اختيار

| DrugBank = DB01026

| ChemSpiderID_Ref =  YesY | ChemSpiderID = 401695 | UNII_Ref =  YesY | UNII = R9400W927I | KEGG_Ref =  YesY | KEGG = D00351 | ChEBI_Ref =  YesY | ChEBI = 48336 | ChEMBL_Ref =  YesY | ChEMBL = 75

| C=26 | H=28 | Cl=2 | N=4 | O=4 | molecular_weight = 531.431 g/mol | smiles = O=C(N5CCN(c4ccc(OC[C@@H]1O[C@](OC1)(c2ccc(Cl)cc2Cl)Cn3ccnc3)cc4)CC5)C | InChI = 1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1 | InChIKey = XMAYWYJOQHXEEK-OZXSUGGEBE | StdInChI_Ref =  YesY | StdInChI = 1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1 | StdInChIKey_Ref =  YesY | StdInChIKey = XMAYWYJOQHXEEK-OZXSUGGESA-N }} كيتوكونازول (Ketoconazole)

الزمرة الدوائية

مضاد فطري يستخدم جهازياً وموضعياً

الاستطبابات

  • علاج الانتانات الفطرية مثل داء المبيضات والسلاق الفموي والفطار البرعمي وداء النوسجات ونظيره الشعيه الكروانيةوداء المبيضات الجلدي المخاطي المزمن وبعض الفطور الجلدية الأخرى
  • يطبق موضعياً لعلاج السعفة الجسد وسعفة الأرفاغ والسعفة المبرقشة وداء المبيضات الجلدي والتهاب الجلد المثي

الاستخدام أثناء الحمل

من المجموعة C

مضادات الاستطباب

  • فرط الحساسية لهذا المستحضر
  • لا يصلح لعلاج الانتان الفطري للجملة العصبية المركزية بسبب ضعف انتشاره فيها
  • لا يجوز إعطاءه مع تيرفينادين أو سيزابريد لأنه قد يسبب لانظميات قلبية مميتة

تحذيرات

يستخدم بحذر عند مرضى الوظيفة الكبدية، وقد ترافق استخدامه أحياناً مع سمية كبدية مميتة