فوستيديل

من موسوعة العلوم العربية
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فوستيديل
Systematic (IUPAC) name
diethyl [4-(1,3-benzothiazol-2-yl)benzyl]phosphonate
Clinical data
Pregnancy cat. ?
Legal status Uncontrolled
Routes Oral
Identifiers
CAS number 75889-62-2
ATC code None
PubChem CID 53421
ChemSpider 48253
UNII D41WS786UL YesY
KEGG D04260
ChEMBL CHEMBL39516
Chemical data
Formula C18NO3PS 
Mol. mass 361.40 g/mol


فوستيديل Fostedil هو موسع وعائي يعمل كحاصر لقنوات الكالسيوم، وكان في طور التطوير لعلاج حالات القلب (كالذبحة الصدرية) ولكنه لم يسوق.[1][2][3][4] له تأثير خافض للضغط ومضاد للروماتيزم.[5][6][7]


الاسماء التجارية

  • 986,A-53
  • KB-944

الاصطناع

Fostedil synthesis.png[8]

مصادر

  1. David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. http://books.google.com/?id=DeX7jgInYFMC&lpg=PA931&dq=Fostedil&pg=PA931#v=onepage&q.
  2. Khurmi NS, Bowles MJ, O'Hara MJ, Lahiri A, Raftery EB (November 1985). "Ambulatory monitoring and exercise testing in the evaluation of a new long-acting calcium ion antagonist KB-944 (Fostedil) for the treatment of exertional angina pectoris". International Journal of Cardiology 9 (3): 289–302. doi:10.1016/0167-5273(85)90027-0. PMID 3902675.
  3. Morita T, Yoshino K, Kanazawa T, Ito K, Nose T (1982). "Vasodilator action of KB-944, a new calcium antagonist". Arzneimittel-Forschung 32 (9): 1037–42. PMID 6890822.
  4. Morita T, Kanazawa T, Ito K, Nose T (1982). "Vasodilator mechanism of KB-944, a new calcium antagonist". Arzneimittel-Forschung 32 (9): 1043–6. PMID 6890823.
  5. Morita T, Kanazawa T, Ito K, Nose T (1982). "Antihypertensive effect of KB-944, a new calcium antagonist, in conscious normotensive and hypertensive rats". Arzneimittel-Forschung 32 (9): 1047–52. PMID 6890824.
  6. Morita T, Ito K, Nose T (1982). "Cardiac action of KB-944, a new calcium antagonist". Arzneimittel-Forschung 32 (9): 1053–5. PMID 6890825.
  7. Yoshidomi M, Sukamoto T, Morita T, Ito K, Nose T (1982). "Antiarrhythmic effect of KB-944, a new calcium antagonist. A comparison with verapamil and diltiazem". Arzneimittel-Forschung 32 (9): 1056–9. PMID 6890826.
  8. Yoshino K, Kohno T, Uno T, Morita T, Tsukamoto G (May 1986). "Organic phosphorus compounds. 1. 4-(Benzothiazol-2-yl)benzylphosphonate as potent calcium antagonistic vasodilator". Journal of Medicinal Chemistry 29 (5): 820–5. doi:10.1021/jm00155a037. PMID 3701791.