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سيكريمين - تاريخ المراجعة
2026-07-03T20:35:44Z
تاريخ التعديل لهذه الصفحة في الويكي
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https://www.arabsciencepedia.org/w/index.php?title=%D8%B3%D9%8A%D9%83%D8%B1%D9%8A%D9%85%D9%8A%D9%86&diff=41126&oldid=prev
أسيل سيوف في 09:10، 19 أبريل 2018
2018-04-19T09:10:53Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">→ مراجعة أقدم</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">مراجعة 09:10، 19 أبريل 2018</td>
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<td colspan="2" class="diff-lineno">سطر 64:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''سيكريمين Cycrimine''' (الاسم التجاري Pagitane) هو دواء مركزي مضاد لل[[كولين]] مصمم لتقليل مستويات [[أستيل كولين]] لعلاج [[مرض باركنسون]].</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''سيكريمين Cycrimine''' (الاسم التجاري Pagitane) هو دواء مركزي مضاد لل[[كولين]] مصمم لتقليل مستويات [[أستيل كولين]] لعلاج [[مرض باركنسون]].</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"> </del>آلية عمله هي الارتباط بمستقبلات [[أستيل كولين]] ال[[مسكارين]]ية M1.<ref>''Psychotropic Drugs and Related Compounds'', 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972, page 218</ref></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>آلية عمله هي الارتباط بمستقبلات [[أستيل كولين]] ال[[مسكارين]]ية M1.<ref>''Psychotropic Drugs and Related Compounds'', 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972, page 218</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==الاصطناع==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==الاصطناع==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">==Synthesis==</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Cycrimine synthesis.png|thumb|center|500px|Cycrimine synthesis:<ref>{{cite journal|last1=Denton|first1=J. J.|last2=Schedl|first2=H. P.|last3=Lawson|first3=Virginia A.|last4=Neier|first4=W. B.|title=Antispasmodics. VII.<sup>1</sup> Additional Morpholinyl and Piperidyl Tertiary Alcohols|journal=Journal of the American Chemical Society|volume=72|issue=8|year=1950|pages=3795–3796|doi=10.1021/ja01164a127}}</ref>]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Cycrimine synthesis.png|thumb|center|500px|Cycrimine synthesis:<ref>{{cite journal|last1=Denton|first1=J. J.|last2=Schedl|first2=H. P.|last3=Lawson|first3=Virginia A.|last4=Neier|first4=W. B.|title=Antispasmodics. VII.<sup>1</sup> Additional Morpholinyl and Piperidyl Tertiary Alcohols|journal=Journal of the American Chemical Society|volume=72|issue=8|year=1950|pages=3795–3796|doi=10.1021/ja01164a127}}</ref>]]</div></td></tr>
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أسيل سيوف
https://www.arabsciencepedia.org/w/index.php?title=%D8%B3%D9%8A%D9%83%D8%B1%D9%8A%D9%85%D9%8A%D9%86&diff=41125&oldid=prev
أسيل سيوف: أنشأ الصفحة ب'{{Drugbox | IUPAC_name = 1-Cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol | image = Cycrimine.svg | width = | alt = | image2 = | width2 = | drug_name = <!--Clini...'
2018-04-19T09:08:15Z
<p>أنشأ الصفحة ب'{{Drugbox | IUPAC_name = 1-Cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol | image = Cycrimine.svg | width = | alt = | image2 = | width2 = | drug_name = <!--Clini...'</p>
<p><b>صفحة جديدة</b></p><div>{{Drugbox<br />
| IUPAC_name = 1-Cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol<br />
| image = Cycrimine.svg<br />
| width =<br />
| alt = <br />
| image2 = <br />
| width2 = <br />
| drug_name = <br />
<!--Clinical data--><br />
| tradename = <br />
| licence_EU = <!-- EMA requires brand name --><br />
| licence_US = Cycrimine<br />
| DailyMedID = <!-- preference to licence_US --><br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--><br />
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --><br />
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM --><br />
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --><br />
| legal_status = <br />
| dependency_liability = <br />
| routes_of_administration = <br />
<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion = <br />
<!--Identifiers--><br />
| CAS_number = 77-39-4<br />
| CAS_supplemental = <br />
| ATCvet = <br />
| ATC_prefix = none<br />
| ATC_suffix = <br />
| ATC_supplemental = <br />
| IUPHAR_ligand = <br />
| DrugBank = DB00942<br />
| ChEBI_Ref = {{ebicite|correct|EBI}}<br />
| ChEBI = 59692<br />
| UNII_Ref = {{fdacite|correct|FDA}}<br />
| UNII = 543567RFQQ<br />
| ChEMBL = 1201227<br />
| synonyms = <br />
| PubChem = 2911<br />
| ChemSpiderID = 2808<br />
| StdInChI = 1S/C19H29NO/c21-19(18-11-5-6-12-18,17-9-3-1-4-10-17)13-16-20-14-7-2-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2<br />
| StdInChIKey = SWRUZBWLEWHWRI-UHFFFAOYSA-N<br />
<!--Chemical data--><br />
| chemical_formula =<br />
| C=19 | H=29 | N=1 | O=1<br />
| molecular_weight = 287.4 g/mol<br />
| SMILES = OC(CCN1CCCCC1)(C2CCCC2)c3ccccc3<br />
| density = <br />
| melting_point = <br />
| melting_high = <br />
| melting_notes = <br />
| boiling_point = <br />
| boiling_notes = <br />
| solubility = <br />
| specific_rotation = <br />
| sec_combustion = <br />
}}<br />
<br />
'''سيكريمين Cycrimine''' (الاسم التجاري Pagitane) هو دواء مركزي مضاد لل[[كولين]] مصمم لتقليل مستويات [[أستيل كولين]] لعلاج [[مرض باركنسون]].<br />
آلية عمله هي الارتباط بمستقبلات [[أستيل كولين]] ال[[مسكارين]]ية M1.<ref>''Psychotropic Drugs and Related Compounds'', 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972, page 218</ref><br />
<br />
==الاصطناع==<br />
==Synthesis==<br />
[[File:Cycrimine synthesis.png|thumb|center|500px|Cycrimine synthesis:<ref>{{cite journal|last1=Denton|first1=J. J.|last2=Schedl|first2=H. P.|last3=Lawson|first3=Virginia A.|last4=Neier|first4=W. B.|title=Antispasmodics. VII.<sup>1</sup> Additional Morpholinyl and Piperidyl Tertiary Alcohols|journal=Journal of the American Chemical Society|volume=72|issue=8|year=1950|pages=3795–3796|doi=10.1021/ja01164a127}}</ref>]]<br />
<br />
==المصدر==<br />
{{مراجع}}<br />
<br />
{{أدوية معالجة داء باركنسون}}<br />
[[تصنيف:أدوية]]<br />
[[تصنيف:موسوعة الأدوية]]<br />
[[تصنيف:أدوية معالجة داء باركنسون]]</div>
أسيل سيوف