https://www.arabsciencepedia.org/w/index.php?action=history&feed=atom&title=%D8%A5%D9%8A%D8%AB%D9%88%D8%B3%D9%88%D9%83%D8%B3%D9%8A%D9%85%D9%8A%D8%AF 2026-04-29T13:29:39Z تاريخ التعديل لهذه الصفحة في الويكي MediaWiki 1.43.6 https://www.arabsciencepedia.org/w/index.php?title=%D8%A5%D9%8A%D8%AB%D9%88%D8%B3%D9%88%D9%83%D8%B3%D9%8A%D9%85%D9%8A%D8%AF&diff=36529&oldid=prev 2015-05-16T05:33:57Z

<p>أنشأ الصفحة ب&#039;{{Drugbox | verifiedrevid = 461096657 | IUPAC_name = (&#039;&#039;RS&#039;&#039;)-3-ethyl-3-methyl-pyrrolidine-2,5-dione | image = Ethosuximide.png | width = 120px | imagename = 1 : 1 mixtu...&#039;</p> <p><b>صفحة جديدة</b></p><div>{{Drugbox<br /> | verifiedrevid = 461096657<br /> | IUPAC_name = (&#039;&#039;RS&#039;&#039;)-3-ethyl-3-methyl-pyrrolidine-2,5-dione<br /> | image = Ethosuximide.png<br /> | width = 120px<br /> | imagename = 1 : 1 mixture (racemate)<br /> | image2 = Ethosuximide ball-and-stick.png<br /> | width2 = 150px<br /> | drug_name = Ethosuximide<br /> <br /> &lt;!--Clinical data--&gt;<br /> | tradename = Zarontin<br /> | Drugs.com = {{drugs.com|monograph|ethosuximide}}<br /> | MedlinePlus = a682327<br /> | pregnancy_category = D &lt;small&gt;(Australia, United States)&lt;/small&gt;<br /> | legal_status = [[Prescription drug|℞-only]] &lt;small&gt;(U.S.)&lt;/small&gt;<br /> | routes_of_administration = Oral<br /> <br /> &lt;!--Pharmacokinetic data--&gt;<br /> | bioavailability = 93%{{ref|bioavailability}}<br /> | metabolism = [[Liver|Hepatic]] ([[CYP3A4]], [[CYP2E1]])<br /> | elimination_half-life = 53 hours<br /> | excretion = [[Kidney|Renal]] (20%)<br /> <br /> &lt;!--Identifiers--&gt;<br /> | CASNo_Ref = {{cascite|correct|CAS}}<br /> | CAS_number_Ref = {{cascite|correct|??}}<br /> | CAS_number = 77-67-8<br /> | ATC_prefix = N03<br /> | ATC_suffix = AD01<br /> | PubChem = 3291<br /> | DrugBank_Ref = {{drugbankcite|correct|drugbank}}<br /> | DrugBank = DB00593<br /> | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}<br /> | ChemSpiderID = 3175<br /> | UNII_Ref = {{fdacite|correct|FDA}}<br /> | UNII = 5SEH9X1D1D<br /> | KEGG_Ref = {{keggcite|correct|kegg}}<br /> | KEGG = D00539<br /> | ChEBI_Ref = {{ebicite|correct|EBI}}<br /> | ChEBI = 4887<br /> | ChEMBL_Ref = {{ebicite|correct|EBI}}<br /> | ChEMBL = 696<br /> <br /> &lt;!--Chemical data--&gt;<br /> | C=7 | H=11 | N=1 | O=2 <br /> | molecular_weight = 141.168 [[Gram|g]]/[[Mole (unit)|mol]]<br /> | smiles = O=C1NC(=O)CC1(C)CC<br /> | InChI = 1/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)<br /> | InChIKey = HAPOVYFOVVWLRS-UHFFFAOYAB<br /> | StdInChI_Ref = {{stdinchicite|correct|chemspider}}<br /> | StdInChI = 1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)<br /> | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}<br /> | StdInChIKey = HAPOVYFOVVWLRS-UHFFFAOYSA-N<br /> }}<br /> <br /> &#039;&#039;&#039;الإيثوسوكسيميد Ethosuximide&#039;&#039;&#039;<br /> <br /> هو الدواء المختار الأول لعلاج نوبات ال[[غيبوبة]] (الصرع الصغير) .<br /> <br /> ==آلية التأثير==<br /> <br /> تثبيط قنوات ال[[كالسيوم]] من النمط T.<br /> <br /> ==مصادر==<br /> <br /> *مقرر [[علم تأثير الأدوية]]، منشورات كلية الصيدلة جامعة دمشق.<br /> <br /> [[تصنيف:أدوية]]<br /> [[تصنيف: موسوعة الأدوية]]<br /> [[تصنيف:مضادات الصرع]]<br /> <br /> {{بذرة}}<br /> {{مضادات الاختلاج}}</div>

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